1. It would be ungrammatical to remove en from that sentence. En + participe présent is a construction to refer to the circumstance in which one performs the action. Just the participe présent by itself doesn’t work.

2. Yes, you can remove vers. The meaning changes from “looking towards the future” to “looking at the future” but it’s still grammatical.

EDIT:
You could remove the en and still have a grammatical sentence where the verb following it qualifies nuages, but without a dash between nuages and the verb. For example

Au-dessus des nuages obscurcissant le ciel — en regardant vers l’avenir — tout ce que vous devez savoir
Above the clouds that darken the sky — looking towards the future — everything that you must know